Napoli moved three points clear at the top of Serie A with a narrow victory at Lecce.
David Neres’ free-kick into the box was headed home by Andre-Frank Zambo Anguissa from close range in the 69th minute as Antonio Conte’s side took the lead.
Leece had a chance to open the scoring after 57 minutes when Francesco Camarda stepped up from the spot but his penalty was well saved by Napoli goalkeeper Vanja Milinkovic-Savic.
The Serb has saved five of the past nine penalties he has faced in Serie A.
The result means Napoli move three points ahead of second-placed Roma having played a game more.
It was Napoli’s first game since Kevin de Bruyne suffered a significant thigh injury which will rule him out for a lengthy period.
The league headers host Como in their next league fixture on Saturday (17:00 GMT).