On February 25, 1999, his immediate predecessor and “senior brother” Otumfuo Opoku Ware II died. Barima Kwaku Duah was selected to succeed Otumfuo Opoku Ware II.

The overwhelming support and universal acclaim he enjoyed from the chiefs and people of the kingdom cemented his choice as the next Asantehene. Consequently, Otumfuo Osei Tutu II was enstooled as the 16th occupant of the Golden Stool on April 26, 1999.